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Article

Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants.

Oncogene - 12 Aug 1999

Yang X, Pater A, Tang S C

Abstract excerpt

BAG-1 is an anti-apoptotic protein that interacts with Bcl-2, Bcl-XL, Hsp70/Hsc70, Raf-1 and numerous hormone or growth factor receptors. Recently, BAG-1 has been found to be overexpressed in a variety of human cancer cell lines and some tumors. However, the molecular mechanism of BAG-1 upregulation is still unclear. In this study, we cloned 0.9 kb of human genomic DNA, BGEV, 5' flanking the BAG-1 open reading...

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Share to Carrier Proteins
Share to Cloning, Molecular
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Transcriptional Activation

Share to Tumor Cells, Cultured

Share to Tumor Suppressor Protein p53

Share to Up-Regulation

Source

Identifiers

PMID: 10467399
DOI: 10.1038/sj.onc.1202843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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