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Article

Insights into the regulation of immunoglobulin light chain gene rearrangements via analysis of the kappa light chain locus in lambda myeloma.

Immunology - 1 Jul 2004

Perfetti Vittorio, Vignarelli Maurizio C, Palladini Giovanni, Navazza Valentina, Giachino Claudia, Merlini Giampaolo

Abstract excerpt

Accumulating evidence indicates that B cells may undergo sequential rearrangements at the light chain loci, despite already expressing light chain receptors. This phenomenon may occur in the bone marrow and, perhaps, in germinal centers. As immunoglobulin (Ig)kappa light chains usually rearrange before Iglambda light chains, we analysed, by polymerase chain reaction, the Igkappa locus of bone marrow mononuclear...

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Share to B-Lymphocytes
Share to Gene Rearrangement, B-Lymphocyte, Light Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

Share to Multiple Myeloma

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Source

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Identifiers

PMID: 15196210
DOI: 10.1046/j.1365-2567.2004.01902.x
PMCID: PMC1782513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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