Article
Variable kappa gene rearrangement in lymphoproliferative disorders: an analysis of V kappa gene usage, VJ joining and somatic mutation.
Leukemia - 1 Jul 1994
Cannell P K, Amlot P, Attard M, Hoffbrand A V, Foroni L
Abstract excerpt
We have studied a diverse group of lymphoproliferative disorders (acute lymphoblastic leukaemia (ALL), chronic lymphocytic leukaemia (CLL), non-Hodgkin lymphoma (NHL) and myeloma) to determine if V kappa gene use is random or disease-specific and whether somatic mutations (a late event in B-cell...
Topics
- Alleles
- B-Lymphocytes
- Base Sequence
- Blotting, Southern
- Gene Rearrangement
- Genes, Immunoglobulin
- Humans
- Immunoglobulin J-Chains
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains