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Article

The frequency of multiple recombination events occurring at the human Ig kappa L chain locus.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1990

Feddersen R M, Martin D J, Van Ness B G

Abstract excerpt

Products of Ig kappa L chain gene rearrangement in a variety of human B cell samples were investigated by sequential Southern blot hybridization analysis. By application of four region-specific probes (C kappa, J kappa, U' kappa and kappa de) a complete spectrum of kappa rearrangements, including both predicted and novel products, were detected. Nearly 30% of the products detected reflect multiple recombination...

Topics

Alleles
Blotting, Southern
DNA Probes
DNA, Neoplasm
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Humans
Immunoglobulin kappa-Chains
Leukemia, B-Cell
Plasmacytoma
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 2104911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2104911-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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