Article
Human lupus anti-DNA autoantibodies undergo essentially primary V kappa gene rearrangements.
The EMBO journal - 1 Jul 1994
Bensimon C, Chastagner P, Zouali M
Abstract excerpt
We have recently characterized the heavy chain variable region (VH) genes expressed by a panel of human anti-DNA antibodies derived from four patients with systemic lupus erythematosus and expressing an idiotypic marker representative of a subset of pathogenic autoantibodies. Here, we have cloned...
Topics
- Amino Acid Sequence
- Antibodies, Antinuclear
- Antibody Diversity
- B-Lymphocytes
- Base Sequence
- Cell Line, Transformed
- Cloning, Molecular
- DNA
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Humans
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Lupus Vulgaris
- Molecular Sequence Data
- Mutation
- Sequence Analysis, DNA