Article
Human lupus anti-DNA autoantibodies undergo essentially primary V kappa gene rearrangements.
The EMBO journal - 1 Jul 1994
Bensimon C, Chastagner P, Zouali M
Abstract excerpt
We have recently characterized the heavy chain variable region (VH) genes expressed by a panel of human anti-DNA antibodies derived from four patients with systemic lupus erythematosus and expressing an idiotypic marker representative of a subset of pathogenic autoantibodies. Here, we have cloned and sequenced the kappa chain variable region genes (V kappa) of the clones whose VH genes had been previously...
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