Article
Immunoglobulin genes in multiple myeloma: expressed and non-expressed repertoires, heavy and light chain pairings and somatic mutation patterns in a series of 101 cases.
Haematologica - 1 Jun 2006
Hadzidimitriou Anastasia, Stamatopoulos Kostas, Belessi Chrysoula, Lalayianni Chrysavgi, Stavroyianni Niki, Smilevska Tatjana, Hatzi Katerina, Laoutaris Nikolaos, Anagnostopoulos Achilles, Kollia Panagoula, Fassas Athanasios
Abstract excerpt
BACKGROUND AND OBJECTIVES: The available data on the immunoglobulin gene (IG) repertoire in multiple myeloma (MM) derive mainly from heavy chains; considerably less is known about light chains. We assessed in parallel IGH and IGK/IGL rearrangements in 101 MM patients so as to gain insight into: (i) IG repertoires; (ii) antigen impact; (iii) the role of receptor editing. DESIGN AND METHODS: Bone marrow aspirates...
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