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Article

Novel recombinations of the IG kappa-locus that result in allelic exclusion.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1990

Feddersen R M, Martin D J, Van Ness B G

Abstract excerpt

Allelic exclusion of Ig H and L chain gene loci serves to ensure that a B cell expresses a single specificity antibody. The analysis of Abelson murine leukemia virus transformed cells that rearrange the kappa-locus during growth in cell culture has provided the opportunity to characterize interme...

Topics

Alleles
Amino Acid Sequence
Animals
B-Lymphocytes
Blotting, Northern
Blotting, Southern
Gene Expression Regulation
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Immunoglobulin kappa-Chains
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Splicing

RNA, Messenger

Source

Identifiers

PMID: 2114448

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2114448-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Novel recombinations of the IG kappa-locus that result in allelic exclusion.PMID 2114448Read ↗

Variegated transcriptional activation of the immunoglobulin kappa locus in pre-b cells contributes to the allelic exclusion of light-chain expression.Semantic proximity Read ↗

Corrective recombination of mouse immunoglobulin kappa alleles in Abelson murine leukemia virus-transformed pre-B cells.Semantic proximity Read ↗

Allelic exclusion of membrane but not secreted immunoglobulin in a mature B cell line.Semantic proximity Read ↗

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Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.Semantic proximity Read ↗

RNA surveillance down-regulates expression of nonfunctional kappa alleles and detects premature termination within the last kappa exon.Semantic proximity Read ↗

Re-organization of the immunoglobulin kappa gene on both alleles is not an obligatory prerequisite for Ig lambda gene expression in human cells.Semantic proximity Read ↗

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A novel type of aberrant T cell receptor alpha-chain gene rearrangement. Implications for allelic exclusion and the V-J recombination process.Semantic proximity Read ↗

The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements.Semantic proximity Read ↗

Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion.Semantic proximity Read ↗

Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion.Semantic proximity Read ↗

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