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Article

Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells.

The Journal of clinical investigation - 1 Apr 1997

Foster S J, Brezinschek H P, Brezinschek R I, Lipsky P E

Abstract excerpt

To analyze the human kappa chain repertoire and the influences that shape it, a single cell PCR technique was used that amplified Vkappa Jkappa rearrangements from genomic DNA of individual human B cells. More than 350 productive and 250 nonproductive Vkappa Jkappa rearrangements were sequenced. Nearly every functional Vkappa gene segment was used in rearrangements, although six Vkappa gene segments, A27, L2, L6,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9120005
DOI: 10.1172/JCI119324
PMCID: PMC507981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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