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Article

Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human.

1 Dec 2001

Abstract excerpt

Southern blot analyses of immunoglobulin light chain gene rearrangements in human leukemias and myelomas indicated that lambda loci in kappa-producing cells are largely unrearranged while kappa loci in lambda producers are often rearranged and inactivated by rearrangements of the kappa-deleting element (KDE). For a systematic analysis of the regulation of light chain rearrangements during early B cell development...

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PMID: 11745383
DOI: 10.1002/1521-4141(200112)31:12<3631::aid-immu3631>3.0.co;2-l

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