Article
Characterization of the immunoglobulin light chain variable region gene expressed in multiple myeloma.
Leukemia - 1 Apr 1998
Kiyoi H, Naito K, Ohno R, Saito H, Naoe T
Abstract excerpt
We studied the organization, diversification and clinical significance of the immunoglobulin light chain (IgL) variable region genes expressed in 17 kappa-chain and 16 lambda-chain producing multiple myeloma (MM) samples. The V genes from 31 MM samples had over 84.9% homology to the known germline Vkappa/lambda genes, whereas one Vkappa and one Vlambda gene had only 75.5% and 65.9% homology, respectively. While...
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