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Article

Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma

19 Jul 2007

Abstract excerpt

The ability to rearrange the germ-line DNA to generate antibody diversity is an essential prerequisite for the production of a functional repertoire. While this is essential to prevent infections, it also represents the "Achilles heel" of the B-cell lineage, occasionally leading to malignant transformation of these cells by translocation of protooncogenes into the immunoglobulin (Ig) loci. However, in...

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PMID: 17634408
DOI: 10.1182/blood-2007-02-069625

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