Article
Epigenetic ontogeny of the Igk locus during B cell development.
Nature immunology - 1 Feb 2005
Goldmit Maya, Ji Yanhong, Skok Jane, Roldan Esther, Jung Steffen, Cedar Howard, Bergman Yehudit
Abstract excerpt
To become accessible for rearrangement, the immunoglobulin kappa locus must undergo a series of epigenetic changes. This begins in pro-B cells with the relocation of both immunoglobulin kappa alleles from the periphery to the center of the nucleus. In pre-B cells, one allele became preferentially packaged into an active chromatin structure characterized by histone acetylation and methylation of histone H3 lysine...
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