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Article

Dynamic changes in accessibility, nuclear positioning, recombination, and transcription at the Ig kappa locus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2007

Fitzsimmons Sean P, Bernstein Ralph M, Max Edward E, Skok Jane A, Shapiro Marjorie A

Abstract excerpt

The 3-megabase Igkappa locus undergoes differentially controlled nuclear positioning events and chromatin structural changes during the course of B cell development. The temporal association of chromatin structural changes, transcription, and recombination at the Igkappa locus was determined in a murine pre-B cell line that can be induced to recombine at the Igkappa locus and in ex vivo-cultured murine pre-B...

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Source

Identifiers

PMID: 17911612
DOI: 10.4049/jimmunol.179.8.5264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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