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Article

PCSK6-mediated corin activation is essential for normal blood pressure.

Nature medicine - 1 Sept 2015

Chen Shenghan, Cao Pengxiu, Dong Ningzheng, Peng Jianhao, Zhang Chunyi, Wang Hao, Zhou Tiantian, Yang Junhua, Zhang Yue, Martelli Elizabeth E, Naga Prasad Sathyamangla V, Miller Rachel E, Malfait Anne-Marie, Zhou Yiqing, Wu Qingyu

Abstract excerpt

Hypertension is the most common cardiovascular disease, afflicting >30% of adults. The cause of hypertension in most individuals remains unknown, suggesting that additional contributing factors have yet to be discovered. Corin is a serine protease that activates the natriuretic peptides, thereby regulating blood pressure. It is synthesized as a zymogen that is activated by proteolytic cleavage. CORIN variants and...

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Identifiers

PMID: 26259032
DOI: 10.1038/nm.3920
PMCID: PMC4710517

Genes

PCSK6
CORIN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PCSK6-mediated corin activation is essential for normal blood pressure.PMID 26259032Read ↗

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