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Article

Correlation between a hepatic copper accumulation and an altered expression of glutathione S-transferase Ya/Yc subunits in LEC mutant rat.

Research communications in chemical pathology and pharmacology - 1 Apr 1992

Yamada T, Izumi K, Suzuki Y, Agui T, Matsumoto K

Abstract excerpt

Long-Evans Cinnamon (LEC) rat, an animal model of Wilson's disease, that develops a necrotizing hepatic injury with an abnormally high hepatic copper accumulation exhibits an altered expression of glutathione S-transferase (GST) subunits, that is, a low percentage of the Ya and a high percentage of the Yc subunit expression in males. The altered expression of GST subunits and the abnormal copper accumulation in...

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PMID: 1518956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Correlation between a hepatic copper accumulation and an altered expression of glutathione S-transferase Ya/Yc subunits in LEC mutant rat.PMID 1518956Read ↗

The rat homologue of the Wilson's disease gene was partially deleted at the 3' end of its protein-coding region in Long-Evans Cinnamon mutant rats.Semantic proximity Read ↗

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Deletion of the Wilson's disease gene in hereditary hepatitis LEC rats.Semantic proximity Read ↗

The WD gene for Wilson's disease links to the hepatitis of LEC rats.Semantic proximity Read ↗

The high hepatocarcinogen susceptibility of LEC rats is genetically independent of abnormal copper accumulation in the liver.Semantic proximity Read ↗

Decreased expression of liver glutathione peroxidase in Long-Evans cinnamon mutant rats predisposed to hepatitis and hepatoma.Semantic proximity Read ↗

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