Correlation between a hepatic copper accumulation and an altered expression of glutathione S-transferase Ya/Yc subunits in LEC mutant rat.

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Article

Correlation between a hepatic copper accumulation and an altered expression of glutathione S-transferase Ya/Yc subunits in LEC mutant rat.

Research communications in chemical pathology and pharmacology - 1 Apr 1992

Yamada T, Izumi K, Suzuki Y, Agui T, Matsumoto K

Abstract excerpt

Long-Evans Cinnamon (LEC) rat, an animal model of Wilson's disease, that develops a necrotizing hepatic injury with an abnormally high hepatic copper accumulation exhibits an altered expression of glutathione S-transferase (GST) subunits, that is, a low percentage of the Ya and a high percentage...

Topics

Animals
Copper
Disease Models, Animal
Gene Expression
Glutathione Transferase
Hepatolenticular Degeneration
Liver
Male
Phenotype
Protein Conformation
Rats
Rats, Inbred BN
Rats, Mutant Strains

Source

Open in PubMed

Identifiers

PMID: 1518956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1518956-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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