Article
DNA damage triggers imbalance of proliferation and apoptosis during development of preneoplastic foci in the liver of Long-Evans Cinnamon rats.
International journal of oncology - 1 Oct 2002
Jia Guang, Tohyama Chiharu, Sone Hideko
Abstract excerpt
The mutant strain Long-Evans Cinnamon (LEC) rat accumulates copper, resulting in spontaneous hepatitis and subsequent development of hepatocellular carcinomas (HCCs) in the liver, providing a promising model for investigation of the relationship between hepatitis induced by oxidative stress and hepatocarcinogenesis. We examined DNA strand breaks in peripheral blood cells and p53 expression in livers during acute...
Topics
- Animals
- Apoptosis
- Cell Division
- Comet Assay
- DNA Damage
- Electrophoresis, Polyacrylamide Gel
- Glutathione S-Transferase pi
- Glutathione Transferase
- Hepatitis
- Immunoblotting
- Immunohistochemistry
- In Situ Nick-End Labeling
- Isoenzymes
- Male