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Increased mutant frequency and altered mutation spectrum of the lacI transgene in Wilson disease rats with hepatitis.

Cancer research - 15 Sept 2000

Sone H, Li Y J, Ishizuka M, Aoki Y, Nagao M

Abstract excerpt

The mutant strain Long-Evans Cinnamon (LEC) rat, which accumulates copper in the liver because of a mutation in the Atp7b gene, encoding a copper-ATPase, is a model of Wilson disease. It spontaneously develops hepatitis, and subsequently hepatocellular carcinoma and cholangiofibrosis. Excess intracellular copper has been thought to induce DNA damage through reactive oxygen species produced by Cu (II)/Cu (I) redox...

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PMID: 11016632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Increased mutant frequency and altered mutation spectrum of the lacI transgene in Wilson disease rats with hepatitis.PMID 11016632Read ↗

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