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Article

Increased polyploid incidence is associated with abnormal copper accumulation in the liver of LEC mutant rat.

Research communications in molecular pathology and pharmacology - 1 Jan 2000

Muramatsu Y, Yamada T, Moralejo D H, Mochizuki H, Sogawa K, Matsumoto K

Abstract excerpt

Long-Evans Cinnamon (LEC) rats are deleted at the p-type copper transport ATPase gene (Atp7b), so that they exhibit abnormal hepatic copper concentration. In this study, it was confirmed that LEC rat liver possesses a feature of increase in polyploid. Furthermore, a segregation analysis using backcrosses between LEC and F344 normal rats showed that the increased polyploid incidence is strongly associated with...

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PMID: 11334362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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