Article
The rat homologue of the Wilson's disease gene was partially deleted at the 3' end of its protein-coding region in Long-Evans Cinnamon mutant rats.
Research communications in molecular pathology and pharmacology - 1 Sept 1995
Muramatsu Y, Yamada T, Moralejo D H, Cai Y, Xin X, Miwa Y, Izumi K, Matsumoto K
Abstract excerpt
LEC mutant rats exhibit an abnormal hepatic copper accumulation, due to the defection of the rat homologue of the Wilson's disease gene. In this study, we found a definitive evidence that the rat Wilson's disease gene of LEC rats was partially deleted at the 3' end of its protein-coding region, b...
Topics
- Animals
- Blotting, Northern
- Blotting, Southern
- Gene Expression
- Hepatolenticular Degeneration
- Liver
- Molecular Structure
- Mutation
- Rats
- Rats, Mutant Strains
- Sequence Homology