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Article

The high hepatocarcinogen susceptibility of LEC rats is genetically independent of abnormal copper accumulation in the liver.

Carcinogenesis - 1 Mar 1995

Hattori A, Sawaki M, Enomoto K, Tsuzuki N, Isomura H, Kojima T, Kamibayashi Y, Sugawara N, Sugiyama T, Mori M

Abstract excerpt

We previously reported that LEC rats, which show a spontaneous occurrence of liver injury and hepatocellular carcinoma (HCC), are highly susceptible to chemical carcinogens such as diethylnitrosamine (DEN). Since abnormal copper accumulation in the liver of LEC rats was found to be a cause of liver injury, it is necessary to elucidate whether the carcinogen susceptibility of LEC rats is related to the...

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Share to Liver Neoplasms, Experimental

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Identifiers

PMID: 7697803
DOI: 10.1093/carcin/16.3.491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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