The high hepatocarcinogen susceptibility of LEC rats is genetically independent of abnormal copper accumulation in the liver.

doi:10.1093/carcin/16.3.491

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Article

The high hepatocarcinogen susceptibility of LEC rats is genetically independent of abnormal copper accumulation in the liver.

Carcinogenesis - 1 Mar 1995

Hattori A, Sawaki M, Enomoto K, Tsuzuki N, Isomura H, Kojima T, Kamibayashi Y, Sugawara N, Sugiyama T, Mori M

Abstract excerpt

We previously reported that LEC rats, which show a spontaneous occurrence of liver injury and hepatocellular carcinoma (HCC), are highly susceptible to chemical carcinogens such as diethylnitrosamine (DEN). Since abnormal copper accumulation in the liver of LEC rats was found to be a cause of liv...

Topics

Animals
Copper
Cytochrome P-450 Enzyme System
Cytochromes b5
Genetic Predisposition to Disease
Liver
Liver Neoplasms, Experimental
Rats
Rats, Inbred F344

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