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Article

The WD gene for Wilson's disease links to the hepatitis of LEC rats.

Japanese journal of cancer research : Gann - 1 Aug 1994

Ono T, Takada S, Yoshida M C

Abstract excerpt

LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime...

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Identifiers

PMID: 7928621
DOI: 10.1111/j.1349-7006.1994.tb02946.x
PMCID: PMC5919571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The WD gene for Wilson's disease links to the hepatitis of LEC rats.PMID 7928621Read ↗

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The Gene Responsible for LEC Hepatitis, Located on Rat Chromosome 16, Is the Homolog to the Human Wilson Disease GeneSemantic proximity Read ↗

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Copper-overload causes cancer? The LEC rat: a model for human hepatitis, liver cancer, and much more.Semantic proximity Read ↗

Absence of linkage between radiosensitivity and the predisposing atp7b gene mutation for heritable hepatitis in the LEC rat.Semantic proximity Read ↗

Fetal copper uptake and a homolog (Atp7b) of the Wilson's disease gene in rats.Semantic proximity Read ↗

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Genomic DNA analyses of spontaneous hepatocellular carcinomas in LEC rat liver using a new technique.Semantic proximity Read ↗

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