Article
The WD gene for Wilson's disease links to the hepatitis of LEC rats.
Japanese journal of cancer research : Gann - 1 Aug 1994
Ono T, Takada S, Yoshida M C
Abstract excerpt
LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed iden...
Topics
- Adenosine Triphosphatases
- Animals
- Base Sequence
- Blotting, Southern
- Copper
- Crosses, Genetic
- DNA Primers
- Female
- Genetic Linkage
- Hepatitis, Animal
- Hepatolenticular Degeneration
- Liver
- Liver Neoplasms
- Male
- Molecular Sequence Data
- Pedigree
- Phenotype
- Polymerase Chain Reaction