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Article

Deletion of the Wilson's disease gene in hereditary hepatitis LEC rats.

Idengaku zasshi - 1 Feb 1995

Ono T, Fukumoto R, Kondoh Y, Yoshida M C

Abstract excerpt

LEC rats develop disorder of cooper metabolism and hepatitis similar to those of human Wilson's disease. We recently demonstrated that the gene responsible for hepatitis (hts) of LEC rats is homologous to Wilson's disease gene (WD). The present study showed a deletion of at least 90 base pair of...

Topics

Animals
Chromosome Mapping
Gene Deletion
Hepatitis, Animal
Hepatolenticular Degeneration
Humans
In Situ Hybridization, Fluorescence
Mutation
Rats
Rats, Inbred Strains

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7772379
DOI: 10.1266/jjg.70.25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7772379-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Deletion of the Wilson's disease gene in hereditary hepatitis LEC rats.PMID 7772379Read ↗

The WD gene for Wilson's disease links to the hepatitis of LEC rats.Semantic proximity Read ↗

The Gene Responsible for LEC Hepatitis, Located on Rat Chromosome 16, Is the Homolog to the Human Wilson Disease GeneSemantic proximity Read ↗

The rat homologue of the Wilson's disease gene was partially deleted at the 3' end of its protein-coding region in Long-Evans Cinnamon mutant rats.Semantic proximity Read ↗

The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease geneSemantic proximity Read ↗

Mapping, cloning and genetic characterization of the region containing the Wilson disease gene.Semantic proximity Read ↗

Fetal copper uptake and a homolog (Atp7b) of the Wilson's disease gene in rats.Semantic proximity Read ↗

Correlation between a hepatic copper accumulation and an altered expression of glutathione S-transferase Ya/Yc subunits in LEC mutant rat.Semantic proximity Read ↗

Isolation and Characterization of a Human Liver cDNA as a Candidate Gene for Wilson DiseaseSemantic proximity Read ↗

Genomic DNA analyses of spontaneous hepatocellular carcinomas in LEC rat liver using a new technique.Semantic proximity Read ↗

Increased mutant frequency and altered mutation spectrum of the lacI transgene in Wilson disease rats with hepatitis.Semantic proximity Read ↗

Copper-overload causes cancer? The LEC rat: a model for human hepatitis, liver cancer, and much more.Semantic proximity Read ↗

Increased polyploid incidence is associated with abnormal copper accumulation in the liver of LEC mutant rat.Semantic proximity Read ↗

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