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Article

Deletion of the Wilson's disease gene in hereditary hepatitis LEC rats.

Idengaku zasshi - 1 Feb 1995

Ono T, Fukumoto R, Kondoh Y, Yoshida M C

Abstract excerpt

LEC rats develop disorder of cooper metabolism and hepatitis similar to those of human Wilson's disease. We recently demonstrated that the gene responsible for hepatitis (hts) of LEC rats is homologous to Wilson's disease gene (WD). The present study showed a deletion of at least 90 base pair of WD cDNA in LEC rats, which corresponds to nucleotides 3981 to 4071 in human WD cDNA sequence. This deletion was linked...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 7772379
DOI: 10.1266/jjg.70.25

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Deletion of the Wilson's disease gene in hereditary hepatitis LEC rats.PMID 7772379Read ↗

The WD gene for Wilson's disease links to the hepatitis of LEC rats.Semantic proximity Read ↗

The Gene Responsible for LEC Hepatitis, Located on Rat Chromosome 16, Is the Homolog to the Human Wilson Disease GeneSemantic proximity Read ↗

The rat homologue of the Wilson's disease gene was partially deleted at the 3' end of its protein-coding region in Long-Evans Cinnamon mutant rats.Semantic proximity Read ↗

The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease geneSemantic proximity Read ↗

Mapping, cloning and genetic characterization of the region containing the Wilson disease gene.Semantic proximity Read ↗

Fetal copper uptake and a homolog (Atp7b) of the Wilson's disease gene in rats.Semantic proximity Read ↗

Correlation between a hepatic copper accumulation and an altered expression of glutathione S-transferase Ya/Yc subunits in LEC mutant rat.Semantic proximity Read ↗

Isolation and Characterization of a Human Liver cDNA as a Candidate Gene for Wilson DiseaseSemantic proximity Read ↗

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Increased mutant frequency and altered mutation spectrum of the lacI transgene in Wilson disease rats with hepatitis.Semantic proximity Read ↗

Copper-overload causes cancer? The LEC rat: a model for human hepatitis, liver cancer, and much more.Semantic proximity Read ↗

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