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Article

Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats.

Japanese journal of cancer research : Gann - 1 Aug 2001

Minami T, Kaneda S, Otsuka T, Jiao Z, Suzuki Y, Yamada T, Matsumoto K, Izumi K

Abstract excerpt

To examine whether Long-Evans Cinnamon (LEC) rats, a mutant rat model of Wilson's disease, have a susceptibility gene(s) to hepatocarcinogenesis in addition to the causative gene, Atp7b, we established a new congenic strain, WKAH.C-Atp7b rats, in which the Atp7b gene of the LEC rats is inserted into the normal Wistar-King Aptekman Hokkaido (WKAH) background. Hepatocellular tumors developed spontaneously in both...

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Identifiers

PMID: 11509115
DOI: 10.1111/j.1349-7006.2001.tb01170.x
PMCID: PMC5903424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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