Article
Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease.
Neurology - 8 Jun 2004
Tiraboschi P, Hansen L A, Masliah E, Alford M, Thal L J, Corey-Bloom J
Abstract excerpt
BACKGROUND: The APOE epsilon4 allele has emerged as a major genetic factor for Alzheimer disease (AD), and its presence has been associated with an increase in beta-amyloid senile plaques (SPs) and neuritic plaques (NPs). Whether it affects neurofibrillary tangle (NFT) accumulation or cholinergic losses in AD remains controversial. In contrast, the epsilon2 allele has been reported to decrease the risk for AD....
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E2
- Apolipoprotein E4
- Apolipoproteins E
- Brain
- California
- Choline O-Acetyltransferase
- Cohort Studies
- Female
- Follow-Up Studies
- Gene Frequency