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Article

Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 2010

Wolk David A, Dickerson Bradford C

Abstract excerpt

The epsilon4 allele of the apolipoprotein E (APOE) gene is the major genetic risk factor for Alzheimer's disease (AD), but limited work has suggested that APOE genotype may modulate disease phenotype. Carriers of the epsilon4 allele have been reported to have greater medial temporal lobe (MTL) pathology and poorer memory than noncarriers. Less attention has focused on whether there are domains of cognition and...

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Identifiers

PMID: 20479234
DOI: 10.1073/pnas.1001412107
PMCID: PMC2890481

Genes

APOE

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Source receipt: pubmed, retrieved 7 Sept 2026.

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