Article
Selective effects of the APOE epsilon4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease.
Neurobiology of disease - 1 Jun 2006
Lai Mitchell K P, Tsang Shirley W Y, Garcia-Alloza Monica, Minger Stephen L, Nicoll James A R, Esiri Margaret M, Wong Peter T-H, Chen Christopher P L-H, Ramírez María J, Francis Paul T
Abstract excerpt
The effects of the APOE epsilon4 allele on a range of pre- and postsynaptic cholinergic markers were studied in a cohort of community-based Alzheimer's disease (AD) patients. Compared with age-matched controls, the postmortem AD neocortex showed decreased choline acetyltransferase (ChAT) and acetyl cholinesterase activities, lower muscarinic M2, and nicotinic alpha4beta2 receptor densities, as well as reduced M1...
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