Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease.

doi:10.1111/j.1749-6632.1996.tb34415.x

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Article

Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease.

Annals of the New York Academy of Sciences - 17 Jan 1996

Beffert U, Poirier J

Abstract excerpt

Apolipoprotein E is a plasma cholesterol and phospholipid transporter which plays a central role in lipoprotein metabolism in the brain. Apolipoprotein E is a polymorphic protein with three common alleles in the general population, designated epsilon 2, epsilon 3 and epsilon 4 coding for proteins...

Topics

Aged
Alzheimer Disease
Amyloid
Amyloid beta-Peptides
Animals
Apolipoproteins E
Brain
Cells, Cultured
Choline O-Acetyltransferase
Female
Genotype
Humans
L-Lactate Dehydrogenase
Male
Neurofibrillary Tangles
Neurons
Rats
Rats, Sprague-Dawley

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