Article
Presence of the apolipoprotein E type epsilon 4 allele is not associated with neurofibrillary pathology or biochemical changes to tau protein.
Dementia and geriatric cognitive disorders - 1 Jan 2000
Mukaetova-Ladinska E B, Harrington C R, Roth M, Wischik C M
Abstract excerpt
Alzheimer's disease (AD) represents a heterogeneous disorder, and several factors have been associated with its development. The presence of the apolipoprotein E type (APOE) epsilon 4 allele has been proposed as a risk factor for AD, but how it influences the development of the characteristic hal...
Topics
- Aged
- Aged, 80 and over
- Amyloid
- Apolipoprotein E4
- Apolipoproteins E
- Female
- Genotype
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Neurofibrillary Tangles
- Polymorphism, Genetic
- tau Proteins