Article
Presence of the apolipoprotein E type epsilon 4 allele is not associated with neurofibrillary pathology or biochemical changes to tau protein.
Dementia and geriatric cognitive disorders - 1 Jan 2000
Mukaetova-Ladinska E B, Harrington C R, Roth M, Wischik C M
Abstract excerpt
Alzheimer's disease (AD) represents a heterogeneous disorder, and several factors have been associated with its development. The presence of the apolipoprotein E type (APOE) epsilon 4 allele has been proposed as a risk factor for AD, but how it influences the development of the characteristic hallmarks of the disease remains unknown. In the present study, the neuropathological changes and levels of both core...
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