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Article

The role of apolipoprotein E in Alzheimer's disease.

Neuron - 13 Aug 2009

Kim Jungsu, Basak Jacob M, Holtzman David M

Abstract excerpt

The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have been numerous studies attempting to elucidate the underlying mechanism for this increased risk, how apoE4 influences AD onset and progression has yet to be proven. However, prevailing evidence suggests that the differential effects of apoE isoforms on Abeta aggregation and clearance...

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Identifiers

PMID: 19679070
DOI: 10.1016/j.neuron.2009.06.026
PMCID: PMC3044446

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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