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Article

Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity.

Scandinavian journal of immunology - 1 Jun 2004

Kristiansen O P, Karlsen A E, Larsen Z M, Johannesen J, Pociot F, Mandrup-Poulsen T

Abstract excerpt

CD4 is a candidate gene in autoimmune diseases, including Type 1 diabetes mellitus (T1DM), because the CD4 receptor is crucial for appropriate antigen responses of CD4(+) T cells. We previously found linkage between a CD4-1188(TTTTC)(5-14) promoter polymorphism and T1DM. In the present study, we screened the human CD4 promoter for mutations and identified three frequent single nucleotide polymorphisms (SNPs):...

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Share to CD4 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 15182254
DOI: 10.1111/j.1365-3083.2004.01444.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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