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Article

CTLA-4 promoter polymorphisms are associated with latent autoimmune diabetes in adults.

Human immunology - 1 Nov 2009

Douroudis Konstantinos, Prans Ele, Uibo Raivo

Abstract excerpt

The cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule is an important regulator of T-cell activation and a susceptibility candidate for autoimmune diseases. To evaluate the impact of CTLA-4 promoter allelic variants of the CTLA-4 gene in latent autoimmune diabetes in adults (LADA), the MH30 (rs231806), -1147 (rs16840252), and -318 (rs5742909) single nucleotide polymorphisms (SNPs) were studied in a population of...

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Share to Alleles
Share to Antigens, CD
Share to CTLA-4 Antigen
Share to Diabetes Mellitus, Type 1
Share to Genetic Predisposition to Disease
Share to Polymorphism, Single Nucleotide
Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 19735686
DOI: 10.1016/j.humimm.2009.09.349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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