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Article

Human CD1a deficiency is common and genetically regulated.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2013

Seshadri Chetan, Shenoy Meera, Wells Richard D, Hensley-McBain Tiffany, Andersen-Nissen Erica, McElrath M Juliana, Cheng Tan-Yun, Moody D Branch, Hawn Thomas R

Abstract excerpt

CD1 proteins evolved to present diverse lipid Ags to T cells. In comparison with MHC proteins, CD1 proteins exhibit minimal allelic diversity as a result of nonsynonymous single nucleotide polymorphisms (SNPs). However, it is unknown if common SNPs in gene regulatory regions affect CD1 expression and function. We report surprising diversity in patterns of inducible CD1a expression on human dendritic cells (DCs),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23858036
DOI: 10.4049/jimmunol.1300575
PMCID: PMC3748949

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