Article
Alleles of the proximal promoter of BAT1, a putative anti-inflammatory gene adjacent to the TNF cluster, reduce transcription on a disease-associated MHC haplotype.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 2003
Wong Agnes M-L, Allcock Richard J N, Cheong Karey Y M, Christiansen Frank T, Price Patricia
Abstract excerpt
BACKGROUND: BAT1 belongs to the DEAD-box family of proteins, and is encoded in the central region of the MHC, a region containing genes affecting immunopathological disorders including Type 1 diabetes. We showed that BAT1 can reduce inflammatory cytokine production, supporting its candidacy as a disease gene. Here we examined the proximal promoter region of BAT1. RESULTS: Ten single nucleotide polymorphisms were...
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