Differential promoter activity by nucleotide substitution at a type 2 diabetes genome-wide association study signal upstream of the wolframin gene.

doi:10.1111/1753-0407.12289

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Article

Differential promoter activity by nucleotide substitution at a type 2 diabetes genome-wide association study signal upstream of the wolframin gene.

Journal of diabetes - 1 Mar 2016

Ryu Jihye, Lee Chaeyoung

Abstract excerpt

BACKGROUND: Functional knowledge of most genetic variants identified from genome-wide association studies (GWAS) for type 2 diabetes (T2D) is limited. A recent T2D GWAS revealed an association signal (rs4689388) upstream of the gene encoding Wolfram syndrome 1 (WFS1) whose intrinsic nucleotide variants had been previously associated with T2D in several candidate gene analyses. The aim of the present study was to...

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PMID: 25800097
DOI: 10.1111/1753-0407.12289

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WFS1

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