Article
Analysis of ancestral and functionally relevant CD5 variants in systemic lupus erythematosus patients.
PloS one - 1 Jan 2014
Cenit Maria Carmen, Martínez-Florensa Mario, Consuegra Marta, Bonet Lizette, Carnero-Montoro Elena, Armiger Noelia, Caballero-Baños Miguel, Arias Maria Teresa, Benitez Daniel, Ortego-Centeno Norberto, de Ramón Enrique, Sabio José Mario, García-Hernández Francisco J, Tolosa Carles, Suárez Ana, González-Gay Miguel A, Bosch Elena, Martín Javier, Lozano Francisco
Abstract excerpt
OBJECTIVE: CD5 plays a crucial role in autoimmunity and is a well-established genetic risk factor of developing RA. Recently, evidence of positive selection has been provided for the CD5 Pro224-Val471 haplotype in East Asian populations. The aim of the present work was to further analyze the functional relevance of non-synonymous CD5 polymorphisms conforming the ancestral and the newly derived haplotypes...
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