Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females

28 Apr 2003

Abstract excerpt

The type 1 diabetes mellitus (T1DM) candidate gene SNP IL6-174G/C was genotyped in 253 Danish T1DM families (1129 individuals). TDT analysis demonstrated linkage in the presence of association between the IL6-174C allele and T1DM in the 416 T1DM offspring, P(tdt)=0.04. Gender conditioned TDT analyses revealed that linkage and association with T1DM were present in females exclusively; P(tdt)=6.5 x 10(-4) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Diabetes and associated disorders
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12719374
DOI: 10.1093/hmg/ddg132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in femalesPMID 12719374Read ↗

Is puberty an accelerator of type 1 diabetes in IL6-174CC females?Semantic proximity Read ↗

<i>IL6</i> Gene Promoter Polymorphisms and Type 2 DiabetesSemantic proximity Read ↗

The IL6-174G/C polymorphism is associated with celiac disease susceptibility in girls.Semantic proximity Read ↗

Effect of the interleukin-6 (-174) g/c promoter polymorphism on adiponectin and insulin sensitivity.Semantic proximity Read ↗

The -174 IL-6 GG genotype is associated with a reduced risk of type 2 diabetes mellitus in a family sample from the National Heart, Lung and Blood Institute's Framingham Heart Study.Semantic proximity Read ↗

Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes.Semantic proximity Read ↗

HLA-G 14-bp polymorphism affects the age of onset in Type I Diabetes Mellitus.Semantic proximity Read ↗

Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity.Semantic proximity Read ↗

A polymorphism in the promoter region of the gene for interleukin-6 is associated with susceptibility to type 1 diabetes mellitus.Semantic proximity Read ↗

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.Semantic proximity Read ↗

[-174 G/C polymorphism of interleukin 6 gene in women with type 1 diabetes].Semantic proximity Read ↗

Fertility is reduced in women and in men with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium (T1DGC)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.