The role of HLA promoters in autoimmunity.

doi:10.2174/138161206778559759

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Article

The role of HLA promoters in autoimmunity.

Current pharmaceutical design - 1 Jan 2006

Müller-Hilke Brigitte, Mitchison N Avrion

Abstract excerpt

Population studies reveal HLA class I and class II gene polymorphisms associated with all the common chronic autoimmune diseases, notably spondylarthropathies, rheumatoid arthritis, multiple sclerosis and type I diabetes. We here discuss the exceptionally high levels of nucleotide diversity in the MHC region likely to reflect not only balancing selection acting on the epitope binding sites but also natural...

Topics

Animals
Anti-Inflammatory Agents
Autoimmune Diseases
Evolution, Molecular
Gene Expression Regulation
Glucocorticoids
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Promoter Regions, Genetic

Source

Open in PubMed

Identifiers

PMID: 17073673
DOI: 10.2174/138161206778559759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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