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Article

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail.

Genes & development - 1 Nov 2003

Jia Jianhang, Tong Chao, Jiang Jin

Abstract excerpt

The Hedgehog (Hh) family of secreted proteins controls many aspects of growth and patterning in animal development. The seven-transmembrane protein Smoothened (Smo) transduces the Hh signal in both vertebrates and invertebrates; however, the mechanism of its action remains unknown. We found that Smo lacking its C-terminal tail (C-tail) is inactive, whereas membrane-tethered Smo C-tail has constitutive albeit low...

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Identifiers

PMID: 14597665
DOI: 10.1101/gad.1136603
PMCID: PMC280620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail.PMID 14597665Read ↗

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