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Article

Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened.

Developmental biology - 1 Apr 2011

Visbal Adriana P, LaMarca Heather L, Villanueva Hugo, Toneff Michael J, Li Yi, Rosen Jeffrey M, Lewis Michael T

Abstract excerpt

The Hedgehog (Hh) signaling network is critical for patterning and organogenesis in mammals, and has been implicated in a variety of cancers. Smoothened (Smo), the gene encoding the principal signal transducer, is overexpressed frequently in breast cancer, and constitutive activation in MMTV-SmoM2 transgenic mice caused alterations in mammary gland morphology, increased proliferation, and changes in...

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Identifiers

PMID: 21276786
DOI: 10.1016/j.ydbio.2011.01.025
PMCID: PMC3057274

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