Article
A normalized identity-by-state statistic for linkage analysis of sib pairs.
Genetic epidemiology - 1 Jan 1999
Nemesure B B, He Q, Mendell N R
Abstract excerpt
A sib-pair analysis was performed on a simulated data set for a fictitious disease, with a prevalence of approximately 3% to 6%. The disease could manifest itself in a severe or mild form and the analyses focused primarily on families with the mild form, barring any misdiagnoses. The numbers of shared genes identical by descent (IBD) and identical by state (IBS) were used to detect linkage between the marker loci...
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