Affected sib pair identity by state analyses.

doi:10.1002/gepi.1370110405

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Article

Affected sib pair identity by state analyses.

Genetic epidemiology - 1 Jan 1994

Thomson G, Motro U

Abstract excerpt

Four methods using identity by state (IBS) data from affected sib pairs are compared for their ability to detect linkage between a diallelic marker and disease. A joint null hypothesis of no linkage and no linkage disequilibrium between the marker and disease must be considered. Two tests have un...

Topics

Gene Frequency
Genes, Recessive
Genetic Diseases, Inborn
Genetic Markers
Genotype
Humans
Linkage Disequilibrium
Models, Genetic
Recombination, Genetic
Reproducibility of Results

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