Article
Affected sib pair identity by state analyses.
Genetic epidemiology - 1 Jan 1994
Thomson G, Motro U
Abstract excerpt
Four methods using identity by state (IBS) data from affected sib pairs are compared for their ability to detect linkage between a diallelic marker and disease. A joint null hypothesis of no linkage and no linkage disequilibrium between the marker and disease must be considered. Two tests have undesirable properties in the case of linkage disequilibrium. Which of the other two tests has more power is dependent on...
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