Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combining identity by descent and association in genetic case-control studies.

BMC genetics - 5 Jul 2008

Zhang Qingrun, Wang Shuang, Ott Jurg

Abstract excerpt

BACKGROUND: In human case-control association studies, one of the chi-square tests typically carried out is based on a 2 x 3 table of genotypes (homogeneity of three genotype frequencies in case and control individuals). We formulate the two degrees of freedom associated with a given genotype distribution in terms of two biologically relevant parameters, (1) the probability F that an individual's two alleles are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Linkage
Share to Chi-Square Distribution
Share to Genes, Dominant

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Recessive

Share to Likelihood Functions

Share to Models, Statistical

Share to Penetrance

Share to Research Design

Source

Open in PubMed Open full text

Identifiers

PMID: 18601744
DOI: 10.1186/1471-2156-9-42
PMCID: PMC2483716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combining identity by descent and association in genetic case-control studies.PMID 18601744Read ↗

Exploiting Hardy-Weinberg equilibrium for efficient screening of single SNP associations from case-control studies.Semantic proximity Read ↗

The power of independent types of genetic information to detect association in a case-control study design.Semantic proximity Read ↗

Adapting the logical basis of tests for Hardy-Weinberg Equilibrium to the real needs of association studies in human and medical genetics.Semantic proximity Read ↗

Genotype relative risks: methods for design and analysis of candidate-gene association studies.Semantic proximity Read ↗

Direct assessment of multiple testing correction in case-control association studies with related individuals.Semantic proximity Read ↗

The epidemiology of genetic epidemiology.Semantic proximity Read ↗

ExactFDR: exact computation of false discovery rate estimate in case-control association studies.Semantic proximity Read ↗

Estimating the degree of identity by descent in consanguineous couples.Semantic proximity Read ↗

A fast, unbiased and exact allelic test for case-control association studies.Semantic proximity Read ↗

Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions.Semantic proximity Read ↗

Do consanguineous parents of a child affected by an autosomal recessive disease have more DNA identical-by-descent than similarly-related parents with healthy offspring? Design of a case-control study.Semantic proximity Read ↗

A note on exact tests of Hardy-Weinberg equilibrium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.