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Article

Detecting rare variant associations by identity-by-descent mapping in case-control studies.

Genetics - 1 Apr 2012

Browning Sharon R, Thompson Elizabeth A

Abstract excerpt

Identity-by-descent (IBD) mapping tests whether cases share more segments of IBD around a putative causal variant than do controls. These segments of IBD can be accurately detected from genome-wide SNP data. We investigate the power of IBD mapping relative to that of SNP association testing for genome-wide case-control SNP data. Our focus is particularly on rare variants, as these tend to be more recent and hence...

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Identifiers

PMID: 22267498
DOI: 10.1534/genetics.111.136937
PMCID: PMC3316661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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