Using affected sib-pairs to uncover rare disease variants.

doi:10.1159/000346788

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Article

Using affected sib-pairs to uncover rare disease variants.

Human heredity - 1 Jan 2012

Perdry Hervé, Müller-Myhsok Bertram, Clerget-Darpoux Françoise

Abstract excerpt

OBJECTIVE: We propose a new test for rare variant mapping, based on an affected sib-pair sample and a control sample. In each sib-pair, only the index case needs to be sequenced, and the number of alleles shared identical-by-descent between the sibs is used as complementary information. The test...

Topics

Genetic Linkage
Genetic Variation
Genotype
Humans
Models, Genetic
Models, Statistical
Rare Diseases
Siblings

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