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Article

Using affected sib-pairs to uncover rare disease variants.

Human heredity - 1 Jan 2012

Perdry Hervé, Müller-Myhsok Bertram, Clerget-Darpoux Françoise

Abstract excerpt

OBJECTIVE: We propose a new test for rare variant mapping, based on an affected sib-pair sample and a control sample. In each sib-pair, only the index case needs to be sequenced, and the number of alleles shared identical-by-descent between the sibs is used as complementary information. The test makes use of both association and linkage information. We compare this test to the Armitage test on case-control data,...

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Identifiers

PMID: 23594491
DOI: 10.1159/000346788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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