Article
Assessing whether an allele can account in part for a linkage signal: the Genotype-IBD Sharing Test (GIST).
American journal of human genetics - 1 Mar 2004
Li Chun, Scott Laura J, Boehnke Michael
Abstract excerpt
To fine map genes, investigators often test for disease-marker association in chromosomal regions with evidence for linkage. Given a marker allele tentatively associated with disease, one would ask if this allele, or one in linkage disequilibrium (LD) with it, could account in part for the observed linkage signal. This question can be addressed by determining if families selected on the basis of the presence of...
Topics
- Computer Simulation
- Data Interpretation, Statistical
- Genetic Linkage
- Genetic Markers
- Genetics, Medical
- Genotype
- Humans
- Software