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Article

A transmission disequilibrium test for general pedigrees that is robust to the presence of random genotyping errors and any number of untyped parents.

European journal of human genetics : EJHG - 1 Sept 2004

Gordon Derek, Haynes Chad, Johnnidis Christopher, Patel Shailendra B, Bowcock Anne M, Ott Jürg

Abstract excerpt

Two issues regarding the robustness of the original transmission disequilibrium test (TDT) developed by Spielman et al are: (i) missing parental genotype data and (ii) the presence of undetected genotype errors. While extensions of the TDT that are robust to items (i) and (ii) have been developed, there is to date no single TDT statistic that is robust to both for general pedigrees. We present here a likelihood...

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Identifiers

PMID: 15162128
DOI: 10.1038/sj.ejhg.5201219
PMCID: PMC1356564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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