Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TDT-HET: a new transmission disequilibrium test that incorporates locus heterogeneity into the analysis of family-based association data.

BMC bioinformatics - 20 Jan 2012

Londono Douglas, Buyske Steven, Finch Stephen J, Sharma Swarkar, Wise Carol A, Gordon Derek

Abstract excerpt

BACKGROUND: Locus heterogeneity is one of the most documented phenomena in genetics. To date, relatively little work had been done on the development of methods to address locus heterogeneity in genetic association analysis. Motivated by Zhou and Pan's work, we present a mixture model of linked and unlinked trios and develop a statistical method to estimate the probability that a heterozygous parent transmits the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to Genome-Wide Association Study

Share to Linkage Disequilibrium

Share to Models, Genetic

Share to Probability

Share to Scoliosis

Source

Open in PubMed Open full text

Identifiers

PMID: 22264315
DOI: 10.1186/1471-2105-13-13
PMCID: PMC3292499

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TDT-HET: a new transmission disequilibrium test that incorporates locus heterogeneity into the analysis of family-based association data.PMID 22264315Read ↗

Detecting linkage disequilibrium in the presence of locus heterogeneity.Semantic proximity Read ↗

TRIO RVEMVS: A Bayesian framework for rare variant association analysis with expectation-maximization variable selection using family trio data.Semantic proximity Read ↗

A haplotype-based framework for group-wise transmission/disequilibrium tests for rare variant association analysis.Semantic proximity Read ↗

A novel test for detecting gene-gene interactions in trio studiesSemantic proximity Read ↗

A Novel Test for Detecting SNP-SNP Interactions in Case-Only Trio Studies.Semantic proximity Read ↗

Multipoint linkage disequilibrium mapping for complex diseases.Semantic proximity Read ↗

Efficient genome-wide association testing of gene-environment interaction in case-parent trios.Semantic proximity Read ↗

A family-based likelihood ratio test for general pedigree structures that allows for genotyping error and missing data.Semantic proximity Read ↗

Causal inference in genetic trio studies.Semantic proximity Read ↗

Transmission disequilibrium test with discordant sib pairs when parents are available.Semantic proximity Read ↗

Assessing genuine parents-offspring trios for genetic association studies.Semantic proximity Read ↗

Benchmarking statistical methods for analyzing parent-child dyads in genetic association studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.