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Article

Transmission disequilibrium test with discordant sib pairs when parents are available.

Human genetics - 1 May 2002

Deng Hong-Wen, Chen Wei-Min, Recker Robert R

Abstract excerpt

The transmission disequilibrium test (TDT) has been employed to map disease susceptibility loci (DSL), while being immune to the problem of population admixture. The customary TDT test (TDT(D)) was developed for affected child(ren) and their parents and was most often applied to case-parent trios. Recently, the TDT has been extended to the situations when (1) parents are not available but affected and nonaffected...

Topics

Alleles
Chromosome Mapping
Computer Simulation
Female
Humans
Linkage Disequilibrium
Male
Models, Genetic
Nuclear Family
Parents
Reproducibility of Results
Sample Size

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12073016
DOI: 10.1007/s00439-002-0675-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12073016-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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