Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers.

doi:10.1086/497345

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Article

Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers.

American journal of human genetics - 1 Nov 2005

Abecasis Gonçalo R, Wigginton Janis E

Abstract excerpt

Single-nucleotide polymorphisms (SNPs) are rapidly replacing microsatellites as the markers of choice for genetic linkage studies and many other studies of human pedigrees. Here, we describe an efficient approach for modeling linkage disequilibrium (LD) between markers during multipoint analysis...

Topics

Algorithms
Chromosomes, Human, Pair 17
Computer Simulation
Genetic Markers
Humans
Linkage Disequilibrium
Markov Chains
Pedigree
Polymorphism, Single Nucleotide
Psoriasis

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