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Article

Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers.

American journal of human genetics - 1 Nov 2005

Abecasis Gonçalo R, Wigginton Janis E

Abstract excerpt

Single-nucleotide polymorphisms (SNPs) are rapidly replacing microsatellites as the markers of choice for genetic linkage studies and many other studies of human pedigrees. Here, we describe an efficient approach for modeling linkage disequilibrium (LD) between markers during multipoint analysis of human pedigrees. Using a gene-counting algorithm suitable for pedigree data, our approach enables rapid estimation...

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Identifiers

PMID: 16252236
DOI: 10.1086/497345
PMCID: PMC1271385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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