Article
Genotype-based association test for general pedigrees: the genotype-PDT.
Genetic epidemiology - 1 Nov 2003
Martin E R, Bass M P, Gilbert J R, Pericak-Vance M A, Hauser E R
Abstract excerpt
Many family-based tests of linkage disequilibrium (LD) are based on counts of alleles rather than genotypes. However, allele-based tests may not detect interactions among alleles at a single locus that are apparent when examining associations with genotypes. Family-based tests of LD based on genotypes have been developed, but they are typically valid as tests of association only in families with a single affected...
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